Generator
B-carotene

Part:BBa_K343006:Design

Designed by: Christian Kurtzhals   Group: iGEM10_SDU-Denmark   (2010-10-14)

Expresses B-carotene monooxygenase on a constitutive promotor


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 765
    Illegal BamHI site found at 500
    Illegal BamHI site found at 1757
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 1361
    Illegal BsaI site found at 1809


Design Notes

1. Source and function

The gene was cloned from Drosophila melanogaster cDNA aquired from Drosophila Genomic Resource Center. The normal function of the gene is to create beta-caroten 15'15-monooxygenase as outlined above. The function of this gene has been characterized in the literature.

2. Modifications before assembly

Appart from addition of BioBrick prefix/suffix no changes were made to the DNA before inserting it into E. coli.

3. Choice of additional parts

We have chosen the J13002 promotr+rbs to avoid both having to ligate promotor and rbs seperately. The B0015 dual terminator because of good experiences from earlier teams.

4. Vector

The gene was inserted into a pSB1C3 backbone.

5. Safety considderations

We considered the gene, the strains of E. coli and plasmids used as safe.